Acetylcholine Transporters

Supporting information

Vesicular acetylcholine transporters (VAChTs) are members of the solute carrier family 18 (SLC18) of ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is found in the central and peripheral nervous systems in cholinergic pre-synaptic vesicle membranes of cholinergic neurons, where it is responsible for maintaining the concentration of acetylcholine (ACh).

Cholinergic synaptic vesicles contain a H+-ATPase, which creates an electrical gradient across the vesicular membrane. VAChT acts as an ACh-H+ antiporter to facilitate the uptake of ACh. Interestingly, the VAChT gene is located within the first intron of the choline acetyltransferase gene (ChAT), the enzyme that catalyzes ACh synthesis from choline and acetyl coenzyme A. This may be to allow co-ordinated regulation of the two proteins.

To view external sources of pharmacological information for Acetylcholine Transporters, please click here: BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human SLC18A3 NM_003055 Q16572
Mouse Slc18a3 NM_021712 O35304
Rat Slc18a3 NM_030996 Q9R0C9

Literature for Acetylcholine Transporters

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Nicotinic ACh Receptors Scientific Review

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Nicotinic ACh Scientific Review

Written by Susan Wonnacott

Nicotinic ACh Receptors Scientific Review

Our Nicotinic Acetylcholine Receptor review summarizes the structure and function of nAChR receptors, and the pharmacological ligands used to study them. Request copy or view PDF today.

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