Deaminases

Supporting information

Deaminases are enzymes that catalyze the hydrolysis of C-NH2 bonds in amino compounds, producing ammonia. They are usually named after their substrate and two well known members of this group are adenosine deaminase (E.C. 3.5.4.4) and cytidine deaminase (E.C. 3.5.4.5).

Adenosine deaminases (ADA) irreversibly convert adenosine into inosine by the removal of an amino group and they are necessary for the breakdown of food and turnover of nucleic acids. Cytidine deaminases convert cytosine and deoxycytosine to uridine and deoxyuridine respectively, and are involved in maintaining the cellular pyrimidine pool. Other members of this group include guanine deaminase (GDA) (converts guanine to xanthine), dCMP deaminase (DCTD) (involved in cytosine metabolism) and porphobilinogen deaminase (PBGD) (involved in heme biosynthesis).

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ADA Human ADA NM_000022 P00813
Mouse Ada NM_007398 P03958
Rat Ada NM_130399 Q920P6
CDA Human CDA NM_001785 P32320
Mouse Cda NM_028176 P56389
Rat Cda NM_001108688 XP_342956
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Literature for Deaminases

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