Adenosine Kinase

Supporting information

Adenosine kinase (ADK) is a highly conserved monomeric enzyme that constitutes the primary route of adenosine metabolism under normal conditions. ADK acts to decrease intracellular adenosine levels by catalyzing its conversion into AMP and ADP, using ATP as a phosphate donor and a divalent cation, for example Mg2+, as a co-factor.

ADK is regulated by inorganic phosphate levels, the concentration of local free Mg2+ and contains a NXXE motif that is vital for phosphate activation. Inhibition of this enzyme has been implicated in tissue-protective mechanisms against various physiological stresses, including ischemia, seizures, pain and inflammation, thus there is much interest in developing pharmacological ADK inhibitors.

To view external sources of pharmacological information for Adenosine Kinase, please click here: BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADK NM_001123 P55263
Mouse Adk NM_134079 P55264
Rat Adk NM_012895 Q64640

Literature for Adenosine Kinase

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
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Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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