Nucleoside Transporters

Supporting information

Nucleoside transporters are divided into two families: the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1-3) display subtype-selective expression patterns; CNT1 is localized primarily to epithelial tissue whereas CNT2 and CNT3 have more widespread distributions.

SLC29 family transporters (ENT1-4) are glycosylated proteins, localized to the plasma and mitochondrial membranes. They are expressed in the heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. They mediate nucleoside influx and efflux and exhibit highest affinity for adenosine.

CNT and ENT transporters play critical roles in nucleoside salvage pathways where they mediate the first step of nucleotide biosynthesis. In addition, these transporters work in concert to terminate adenosine signaling and are vital determinants in the response to a variety of cancer and antiviral treatments, as they modulate the entry of these nucleoside analogs into target tissues.

To view external sources of pharmacological information for Nucleoside Transporters, please click here: BJP Guide

View all products for Nucleoside Transporters »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CNT1 Human SLC28A1 NM_201651 O00337
Mouse Slc28a1 NM_001004184 NP_001004184
Rat Slc28a1 NM_053863 Q62674
CNT2 Human SLC28A2 NM_004212 O43868
Mouse Slc28a2 NM_172980 O88627
Rat Slc28a2 NM_031664 Q62773
View all Nucleoside Transporter Gene Data »

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