Bcl-2 Family

Supporting information

Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. They comprise a large protein family and all members contain at least one of four BH (Bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-XL and Mcl-1 are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.

The proapoptotic group of Bcl-2 proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (including Bid, NOXA, PUMA and Bad) and the multidomain proteins that share BH1 to 3 (including Bax and Bak). Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes.

The Bcl-2 gene has been linked to the development and therapeutic resistance of numerous different cancers.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Bcl-2 Human BCL2 NM_000633 P10415
Mouse Bcl2 NM_009741 P10417
Rat Bcl2 NM_016993 P49950
Bcl-xL, Bcl-xS Human BCL2L1 NM_138578 Q07817
Mouse Bcl2l1 NM_009743 Q64373
Rat Bcl2l1 NM_001033672 P53563
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Literature for Bcl-2 Family

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Cancer Research Product Guide
Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

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Neurodegeneration Product Guide
Parkinson's Life Science Poster

Written by Anthony H.V. Schapira, this poster summarizes the neurobiology of Parkinson's disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis. This poster also presents new and emerging therapeutic strategies to delay the onset and progress of PD. Compounds available from Tocris are listed.

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Parkinson's Life Science Poster
Programmed Cell Death Life Science Poster

Written by Bram van Raam & Guy Salvesen, this poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

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Programmed Cell Death Life Science Poster
Apoptosis Signaling Pathway
Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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Parkinson's disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

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Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

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