VEGFR

Supporting information

Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and vasculogenesis.

Whilst multiple receptors and ligands are involved in angiogenesis, VEGF signaling is one of the most important, rate-limiting steps of the process. VEGF is diffusible and selective for vascular endothelial cells, and possesses the ability to promote the growth and survival of these cells in vitro. Hypoxic conditions activate hypoxia-inducible factor 1 (HIF-1), resulting in increased VEGF mRNA expression. Other growth factors such as EGF, TGF-β and PDGF may also upregulate VEGF expression. The increased expression levels of VEGF in solid tumors, hematological malignancies, age-related macular degeneration (AMD), diabetes mellitus and various inflammatory disorders has placed great emphasis on developing VEGF inhibitors.

VEGF binds to and activates the receptor tyrosine kinase, VEGFR. Three VEGFR isoforms have been identified in humans: VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4) VEGFR-2 mediates the majority of cellular responses to VEGF, in particular its mitogenic and angiogenic effects. VEGFR-1 is thought to modulate VEGFR-2 signaling or to act as a dummy/decoy receptor to sequester VEGF away from VEGFR-2. The expression of VEGFR-1 is also up-regulated by hypoxia, in a similar mechanism to VEGF, via HIF-1; its functions may vary depending on cell type and developmental stage.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
VEGFR-1 Human FLT1 NM_002019 P17948
Mouse Flt1 NM_010228 P35969
Rat Flt1 NM_019306 P53767
VEGFR-2 Human KDR NM_002253 P35968
Mouse Kdr NM_010612 P35918
Rat Kdr NM_013062 O08775
View all VEGF Receptor Gene Data »

Literature for VEGFR

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Cancer Research Product Guide
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinases Product Listing
Angiogenesis in Cancer Life Science Poster

Angiogenesis is the generation of new blood vessels from pre-existing vasculature. It is a hallmark of cancer and plays a key role in enabling tumor growth, progression and metastasis. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster discusses differences between normal angiogenesis physiology, and tumor vascularization, and highlights therapeutic targets aimed at suppressing angiogenesis.

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Angiogenesis in Cancer Life Science Poster
VEGF Signaling Pathway
VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.

View pathway | Download PDF

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Angiogenesis in Cancer

Taken from the Cancer Guide Edition 3

Angiogenesis in Cancer Life Science Poster

Our Angiogenesis in Cancer poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets. Request copy or view PDF today.

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VEGF Pathway

VEGF Signaling Pathway

VEGF signaling regulates vascular development (vasculogenesis) and the formation of new blood vessels (angiogenesis). View pathway or download PDF today.

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