PDGFR

Supporting information

Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer.

There are two isoforms of the PDGFR receptor; PDGFRα and PDGFRβ, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI3K and PKCγ pathways.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PDGFRα Human PDGFRA NM_006206 P16234
Mouse Pdgfra NM_001083316 P26618
Rat Pdgfra NM_012802 P20786
PDGFRβ Human PDGFRB NM_002609 P09619
Mouse Pdgfrb NM_008809 P05622
Rat Pdgfrb NM_031525 Q003I6

Literature for PDGFR

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Cancer Research Product Guide
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinases Product Listing
Angiogenesis in Cancer Poster

Angiogenesis is the generation of new blood vessels from pre-existing vasculature. It is a hallmark of cancer and plays a key role in enabling tumor growth, progression and metastasis. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster discusses differences between normal angiogenesis physiology, and tumor vascularization, and highlights therapeutic targets aimed at suppressing angiogenesis.

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Angiogenesis in Cancer Poster

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Angiogenesis in Cancer

Taken from the Cancer Guide Edition 3

Angiogenesis in Cancer Poster

Our Angiogenesis in Cancer poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets. Request copy or view PDF today.

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