JAK Kinase

Supporting information

JAKs (or Janus kinases) are a family of tyrosine kinases that are associated with cytokine receptors. Upon receptor activation JAKs phosphorylate the transcription factors known as STATs and initiate the JAK-STAT signaling pathway. Four JAK family members have been identified (JAK1, JAK2, JAK3 and Tyk2), which share a similar protein domain structure: a kinase domain, a regulatory 'pseudo'-kinase domain, a SH2 domain and a FERM domain.

The FERM domain of JAK family members mediates the association of JAK with other enzymes and cytokine receptors. The JAK Tyk2 associates with the IFN-1, IL-6, 10, 12, and 23 cytokine receptor families. JAK1 mediates signals from IFN-α,β,γ and IL-2, 6 receptors. JAK2 transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-γ receptors. JAK3 associates with the IL-2 receptor γ-chain.

Recent research has highlighted a regulatory role for JAK2 in the phosphorylation of histone proteins. This key epigenetic modification results in changes in chromatin architecture and therefore gene expression.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
JAK1 Human JAK1 NM_002227 P23458
Mouse Jak1 NM_146145 P52332
Rat Jak1 NM_002227 P23458
JAK2 Human JAK2 NM_004972 O60674
Mouse Jak2 NM_008413 Q62120
Rat Jak2 NM_031514 Q62689
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Literature for JAK Kinase

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Cancer Research Product Guide
Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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  • Inflammation
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Immunology Product Listing
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Kinases Product Listing
JAK-STAT Signaling Pathway
JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.

View pathway | Download PDF

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

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JAK-STAT Pathway

JAK-STAT Signaling Pathway

JAK-STAT signaling is involved in many fundamental cellular processes such as cell proliferation and hematopoiesis. View pathway or download PDF today.

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