Protein Kinase G

Supporting information

Protein kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2. Due to alternative exon splicing two isoforms of PKG1, PKG1α and PKG1β, exist.

PKG1 and PKG2 are expressed in different cell types, with PKG1 at its highest concentrations in smooth muscle cells and platelets, whilst PKG2 is most abundant in the brain, lungs and intestinal mucosa. PKGs exist as antiparallel homodimers and have roles in smooth muscle relaxation (via phosphorylation of myosin light chain phosphatase), platelet function, spermatozoa metabolism and hemodynamic homeostasis. In addition, it has been suggested that PKG has anticancer properties due to its role in upregulating expression of the tumor suppressor genes p21, p27 and histidine triad protein 1 (HINT1).

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PKG1 Human PRKG1 NM_006258 Q13976
Mouse Prkg1 NM_001013833 Q9Z0Z0
Rat Prkg1 NM_001105731 XP_219805
PKG2 Human PRKG2 NM_006259 Q13237
Mouse Prkg2 NM_008926 Q61410
Rat Prkg2 NM_013012 Q64595

Literature for Protein Kinase G

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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Cancer Research Product Guide
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinases Product Listing
Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Pain Research Product Guide
Angiogenesis Life Science Poster

Written by Yongping Crawford and Napoleone Ferrara, this poster highlights major targets for antiangiogenic therapy, namely tumor- and stromal cell-derived pathways. Intrinsic and acquired resistance are described; antiangiogenic therapies targeting the VEGF pathway are also summarized. Compounds available from Tocris are listed.

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Angiogenesis Life Science Poster

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
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Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

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Neuroscience 2016

Neuroscience 2016

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