Akt (Protein Kinase B)

Supporting information

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane via the PH (pleckstrin homology domain) of Akt.

Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478 (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2).

There are three isoforms of Akt: Akt 1, 2 and 3 (also known as PKBα, β and γ).

To view external sources of pharmacological information for Akt (Protein Kinase B), please click here: BJP Guide

View all products for Akt (Protein Kinase B) »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AKT1 (PKBα) Human AKT1 NM_005163 P31749
Mouse Akt1 NM_009652 P31750
Rat Akt1 NM_033230 P47196
AKT2 (PKBβ) Human AKT2 NM_001626 P31751
Mouse Akt2 NM_001110208 Q60823
Rat Akt2 NM_017093 P47197
View all Akt Gene Data »

Literature for Akt (Protein Kinase B)

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Request copy | Download PDF | View all Product Guides & Listings
Kinases Product Listing
Angiogenesis Life Science Poster

Written by Yongping Crawford and Napoleone Ferrara, this poster highlights major targets for antiangiogenic therapy, namely tumor- and stromal cell-derived pathways. Intrinsic and acquired resistance are described; antiangiogenic therapies targeting the VEGF pathway are also summarized. Compounds available from Tocris are listed.

Request copy | View all posters
Angiogenesis Life Science Poster
Schizophrenia Life Science Poster

Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.

Request copy | View all posters
Schizophrenia Life Science Poster
Akt Signaling Pathway
Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.

View pathway | Download PDF

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

Akt Pathway

Akt Signaling Pathway

Akt signaling is involved in fundamental cellular processes such as protein synthesis, metabolism, proliferation and survival. View pathway or download PDF today.

divider line

Bio-Techne Events

IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2