Myosin Light Chain Kinases

Supporting information

Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction.

In addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes including control of endothelial and vascular permeability, growth initiation of astrocytes processes, neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.

To view external sources of pharmacological information for Myosin Light Chain Kinases, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MLCK1 Human MYLK NM_053025 Q5MYA0
Mouse Mylk NM_139300 Q6PDN3
Rat Mylk NM_001105874 XP_213611
MLCK2 Human MYLK2 NM_033118 Q9H1R3
Mouse Mylk2 NM_001081044 Q8VCR8
Rat Mylk2 NM_057209 P20689
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Literature for Myosin Light Chain Kinases

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