Diacylglycerol Kinases

Supporting information

Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKα, DGKβ, DGKγ, DGKδ, DGKε, DGKζ, DGKη, DGKθ, DGKι and DGKκ) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C′-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies.

DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKα), some are membrane-bound (for example DGKγ is associated with the Golgi membrane) and some are nuclear (for example DGKζ). DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
DGKα Human DGKA NM_201554 P23743
Mouse Dgka NM_016811 O88673
Rat Dgka NM_080787 P51556
DGKβ Human DGKB NM_004080 Q9UQ29
Mouse Dgkb NM_178681 Q6NS52
Rat Dgkb NM_019304 P49621
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Literature for Diacylglycerol Kinases

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