CaM Kinase

Supporting information

Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity.

There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed ubiquitously. Some subtypes display specific distributions, for example, CaMKIVβ is expressed exclusively in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

To view external sources of pharmacological information for CaM Kinase, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CaMKI Human CAMK1 NM_003656 Q14012
Mouse Camk1 NM_133926 Q91YS8
Rat Camk1 NM_134468 Q63450
CaMKIδ Human CAMK1D NM_020397 Q8IU85
Mouse Camk1d NM_177343 Q8BW96
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Literature for CaM Kinase

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Cancer Research Product Guide

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Kinases Product Listing

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