Glucagon and Related Receptors
Glucagon and related peptide receptors are a group of G-protein-coupled receptors that are currently classified into six subtypes; Glucagon, Glucagon-Like Peptide 1 (GLP-1), GLP-2, Secretin, Growth Hormone Releasing Hormone (GHRH) and Gastric Inhibitory Peptide (GIP) based on their pharmacology. This family of class II G-protein-coupled receptors serve multiple biological functions including the regulation of nutrient homeostasis through effects on islet hormone secretion, gastrointestinal motility and cell proliferation.
Glucagon and Related Receptor Target Files
The following table summarizes the properties of the glucagon and related peptide receptors and highlights the products available from Tocris in this subject area.
|G protein||Gs||Gs||Gs||Gs / Gq||Gs||Gs|
|Receptor Localisation||Pancreas, liver, kidneys||Pancreas, CNS, stomach, heart||CNS, GI tract||Pancreas, GI tract, CNS||Anterior pituitary, placenta, kidney||Pancreas, CNS|
|Tissue Functions||Glucoregulation; controls glycogenolysis and gluconeogenesis via regulation of insulin secretion||Glucoregulation; stimulates insulin secretion and suppresses glucagon secretion||Maintains growth and absorptive function of the intestinal mucosal villus epithelium||Regulates pancreatic exocrine and gastric secretions||Regulates pituitary growth hormone synthesis and secretion||Glucoregulation; potentiates insulin secretion|
Glucagon (1-29) amide (2216)
Glucagon-like peptide 1 (7-36) amide (2082)
Glucagon-like peptide 1 (1-37) (1851)
Exendin-3 (9-39) amide (2081)
GLP-1 (9-36) amide (3266)
GLP-2 (human) (2258)
GLP-2 (rat) (2259)
Secretin (human) (1918)
Secretin (rat) (1919)
GIP (1-39) (2257)
GIP (human) (2084)
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