Glucagon and Related Receptors

Glucagon and related peptide receptors are a group of G-protein-coupled receptors that are currently classified into six subtypes; Glucagon, Glucagon-Like Peptide 1 (GLP-1), GLP-2, Secretin, Growth Hormone Releasing Hormone (GHRH) and Gastric Inhibitory Peptide (GIP) based on their pharmacology. This family of class II G-protein-coupled receptors serve multiple biological functions including the regulation of nutrient homeostasis through effects on islet hormone secretion, gastrointestinal motility and cell proliferation.

Glucagon and Related Receptor Target Files

The following table summarizes the properties of the glucagon and related peptide receptors and highlights the products available from Tocris in this subject area.

Receptor Subtype Glucagon GLP-1 GLP-2 Secretin GHRH GIP
G protein Gs Gs Gs Gs / Gq Gs Gs
Receptor Localisation Pancreas, liver, kidneys Pancreas, CNS, stomach, heart CNS, GI tract Pancreas, GI tract, CNS Anterior pituitary, placenta, kidney Pancreas, CNS
Tissue Functions Glucoregulation; controls glycogenolysis and gluconeogenesis via regulation of insulin secretion Glucoregulation; stimulates insulin secretion and suppresses glucagon secretion Maintains growth and absorptive function of the intestinal mucosal villus epithelium Regulates pancreatic exocrine and gastric secretions Regulates pituitary growth hormone synthesis and secretion Glucoregulation; potentiates insulin secretion
Selective Products L-168,049 (2311)
des-His1-[Glu9]-
Glucagon (1-29) amide (2216)
Glucagon-like peptide 1 (7-36) amide (2082)
Glucagon-like peptide 1 (1-37) (1851)
Exendin-4 (1933)
Exendin-3 (9-39) amide (2081)
GLP-1 (9-36) amide (3266)
GLP-2 (human) (2258)
GLP-2 (rat) (2259)
Secretin (human) (1918)
Secretin (rat) (1919)
GRF (ovine) GIP (1-39) (2257)
GIP (human) (2084)

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Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

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Appetite Modulation

Written by S. Tucci et al

Peptides Involved in Appetite Modulation Scientific Review

Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis. View PDF today.

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Gut Hormones and the Regulation of Appetite

Written by V.J. Taylor et al

Gut Hormones Life Science Poster

Our Gut Hormones and the Regulation of Appetite poster gives an overview of the neuropeptide modulators and gut hormones that influence appetite. Request copy today.

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