www.tocris.com
Cannabinoid Receptor Ligands Available from Tocris
Agonists
1120 AM 630
1297 Abn-CBD
CB 2 selective antagonist/inverse agonist
Agonist for putative abnormal-CBD receptor
1319 ACEA
Selection of 3 CB 1 receptor ligands (Cat. Nos. 1319, 1121 and 1117)
Potent, highly selective CB 1 agonist
1318 ACPA
Selection of 5 endogenous cannabinoids (Cat. Nos. 1339, 1298, 1568,
Potent, selective CB 1 agonist
1411 and 1569)
2479 JTE 907
Potent, selective CB 1 agonist (in water-soluble emulsion)
CB 2 -selective antagonist/inverse agonist
1339 Anandamide
2387 LY 320135
Endogenous CB receptor agonist
Selective CB 1 receptor antagonist/inverse agonist
2288 O-1918
Endogenous CB receptor agonist (in water-soluble emulsion)
Silent antagonist for putative abnormal-CBD receptor
1655 O-2050
Endogenous cannabinoid agonist
CB 1 silent antagonist
1354 Arvanil
Potent CB 1 and TRPV1 agonist/anandamide transport inhibitor
Endogenous CB 1 partial agonist/antagonist. Also CB 2 agonist
CB 1 /CB 2 receptor partial agonist
CB 2 antagonist/CB 1 partial inverse agonist. Enantiomer of Cat. No.
1038
Selection of 3 CB 1 receptor ligands (Cat. Nos. 1319, 1121 and 1117)
Other
1462
Selection of 5 cannabinoid receptor agonists (Cat. Nos. 1339, 1298,
Inhibits anandamide hydrolysis
0949, 0966 and 1038)
1116
0949 CP 55,940
Anandamide transport inhibitor
Potent CB 1 and CB 2 agonist
1485 DEA
Anandamide transport inhibitor (in water-soluble emulsion)
Endogenous CB 1 agonist
Inhibits pain in vivo
Selection of 5 endogenous cannabinoids (Cat. Nos. 1339, 1298, 1568,
1411 and 1569)
Novel endocannabinoid. Suppresses pain in vivo
2374 GW 405833
1383 BML-190
Selective, high affinity CB 2 receptor partial agonist
Potent, selective CB 2 ligand
0966 HU 210
Highly potent cannabinoid agonist
Natural cannabinoid; weak CB 1 antagonist and AMT inhibitor.
1341 JWH 015
Anticonvulsive in vivo
Selective CB 2 agonist
2231 Anti-CB 2
1343 JWH 133
Antibody recognising CB 2 receptors
Potent, selective CB 2 agonist
Blocking peptide for Cat. No. 2231
Potent, selective CB 2 agonist (in water-soluble emulsion)
2433 L-759,633
Metabolically stable anandamide transport inhibitor
High affinity, selective CB 2 agonist
2452 LY 2183240
2434 L-759,656
Novel, potent anandamide uptake inhibitor. Inhibits FAAH
Highly selective CB 2 agonist
1421 MAFP
2139 Leelamine
Potent, irreversible anandamide amidase inhibitor
CB 1 agonist
1446 O-2093
Inverse agonist at a non-CB 1 , non-TRPV1 site. Active in vivo
Potent and selective CB 1 agonist
Anandamide analogue, anorexic agent
Potent and selective CB 1 agonist (in water-soluble emulsion)
1797 OMDM-2
1568 NADA
Potent inhibitor of anandamide uptake
Endogenous CB 1 agonist. Also vanilloid agonist and inhibitor of FAAH
and AMT
Agonist for putative CB 2 -like receptor. FAAH and PAA substrate
2206 2-Palmitoylglycerol
Endogenous agonist for CB 1
Endogenous lipid; enhances activity of 2-AG
0878 Oleamide
CB 1 receptor agonist
Inhibitor of FAAH
Agonist for putative CB 2 -like receptor. FAAH and PAA substrate
Collection of cannabinoid receptor and related compounds
Endogenous CB 2 agonist. Also CB 1 partial agonist/antagonist
Water-soluble emulsion; negative control for Cat. Nos. 1017, 1685,
1686, 1781, 1782 and 1783
Highly potent cannabinoid agonist
1966 UCM 707
Antagonists
Potent anandamide transport inhibitor
1117
1392 VDM 11
Potent, selective CB 1 antagonist/inverse agonist
Potent, selective anandamide transport inhibitor
1115
Potent, selective CB 1 antagonist/inverse agonist
Potent, selective anandamide transport inhibitor (in water-soluble
emulsion)
Please note, the product names used in this review are assigned according to the nomenclature employed by Tocris in its catalogue and website.
Tocris Reviews No. 27
©2006 Tocris Cookson
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