1/3 Raf RTK Raf Ras Ras Hsps p53 p53 PLC PKC PKA p90 RSK EGF p90 RSK Apoptosis Integrin
Receptor FAK Src PI3K Rac Rac cAMP p38
MAPK ASK c-Myc
The mitogen-activated protein kinase (MAPK) family is a group of serine/threonine kinases that mediate intracellular signaling. The activation of MAPK involves a cascade consisting of MAPK kinase (also known as MAPKKK or MEKK) that activates MAPK/ERK (also known as MAPKK or MEK). This stimulates a phosphorylation-dependent increase in the activity of MAPK.
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