Featured Products 2017

Highlighted products added to the Tocris Bioscience range during 2017

January 2017

Potent BRD9/7 inhibitor
6000 | TP 472

Kd values are 33 and 340 nM, respectively. Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo

Related Products: (+)-JQ1 I-BET 151 I-BRD9
Raf kinase and VEGFR-2 inhibitor
6015 | RAF 265

Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable.

Related Products: SU 5416 SU 5402 GDC 0879
Endogenous amylin, calcitonin, CGRP and adrenomedullin agonist
6030 | Amylin (rat)

pEC50 values are 7.06-9.50 at hCTa, 8.11 at rCTa, 7.73-10.1 at hAMY1a, 9.74 at rAMY1a, 7.92 at hAMY1b, 7.78-9.9 at hAMY2a, 7.94 at hAMY2b, 8.09-10.8 at hAMY3a, 9.97 at rAMY and 8.19 at hAMY3b receptors. Suppresses insulin-stimulated glucose uptake. Delays gastric emptying and promotes satiety. Active in vivo.

Related Products: CGRP (rat) AC 187 Pramlintide
Potent soluble guanylyl cyclase (sGC) activator
6052 | BAY 58-2667

EC50 = 6.4 nM. Binds heme-free sGC. Exhibits antihypertensive effects in vivo.

Related Products: YC 1 BAY 41-2272 BAY 41-8543
Oct4 activator; enhances iPSC reprogramming efficiency
6066 | OAC-2

Enhances iPSC reprogramming four-fold and accelerates the appearance of iPSC colonies in combination with 4F (Oct4, Sox2, c-Myc and Klf4). Also induces cardiomyocyte-like cells from human fibroblasts, as part of the 9C cocktail (CHIR 99021, A83-01, BIX 01294, AS83541, SC1, Y-27632, SU 16f, JNJ10198409 and OAC-2)

Related Products: Y-27632 CHIR 99021 O4I1

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Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2017

Epigenetic Regulation of Stem Cell Differentiation

March 1, 2017

Amsterdam, The Netherlands