Cat. No. 2025
Alternative Name: Ro 24-5913
Chemical Name: 4-[[3-[(1E)-2-(4-Cyclobutyl-2-thiaz
Biological ActivityPotent, selective CysLT1 (LTD4) leukotriene receptor antagonist (IC50 = 6.4 nM). Inhibits LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
O'Donnell (1991) Ro 24-5913: a potent, specific, orally active LTD4 antagonist. Ann.N.Y.Acad.Sci. 629 413. PMID: 1659286.
O'Donnell et al (1991) Pharmacologic actions of Ro 24-5913, a novel antagonist of leukotriene D4. J.Pharmacol.Exp.Ther. 259 751. PMID: 1658310.
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Keywords: Cinalukast, supplier, Potent, selective, CysLT1, LTD4, antagonists, orally, active, Receptors, LTE4, leukotrienes, eicosanoids, Ro245913, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products
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