Cat. No. 2018
Alternative Names: Org 3770, 6-Azamianserin
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methylpy
Biological ActivityAntidepressant agent; potent 5-HT2, 5-HT3 and histamine H1 receptor antagonist and moderately potent α2-adrenoceptor antagonist (pKi values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pKi values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
de Boer et al (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazepine, mianserin and idazoxan. J.Pharmacol.Exp.Ther. 277 852. PMID: 8627567.
Kooyman et al (1994) Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 33 501. PMID: 7984289.
de Boer et al (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 27 399. PMID: 3419539.
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Citations are publications that use Tocris products. Selected citations for Mirtazapine include:
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Cancer Res 7 2336. PMID: 26114334.
Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395. PMID: 21966518.
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Keywords: Mirtazapine, supplier, Potent, 5-HT3, antagonists, 5-HT2, H1, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Antidepressant, Serotonin, Receptors, Non-Selective, Histamine, histaminergic, Org3770, Tocris Bioscience, Non-selective 5-HT2 Antagonist products