PSB 11 hydrochloride

Cat. No. 2012

PSB 11 hydrochloride C16H17N5O.HCl [453591-58-7]

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Chemical Name: (8R)-8-Ethyl-1,4,7,8-tetrahydro-4-5H-imidazo[2,1-i]purin-5-one hydrochloride

Biological Activity

Potent and selective antagonist for the human adenosine A3 receptor, with low affinity for the rat A3 receptor (Ki values are 2.3 and > 10000 nM respectively). Displays > 1000-fold selectivity over human A1 and A2A receptors (Ki values are 4.1 and 3.3 μM respectively) and > 180-fold selectivity over rat A1, rat A2A and mouse A2B receptors. Acts as an inverse agonist in the [35S]GTPγS binding assay in hA3-CHO cells (IC50 = 36 nM).

Technical Data

M.Wt:
331.8
Formula:
C16H17N5O.HCl
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
453591-58-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Muller (2003) Medicinal chemistry of adenosine A3 receptor ligands. Curr.Top.Med.Chem. 3 445. PMID: 12570761.

Ozola et al (2003) 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A3 adenosine receptors. Bioorg.Med.Chem. 11 347. PMID: 12517430.

Muller et al (2002) Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A2A- and A3-adenosine receptor antagonists. J.Med.Chem. 45 3440. PMID: 12139454.

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Keywords: PSB 11 hydrochloride, supplier, Potent, selective, human, A3, receptor, antagonists, inverse, agonists, Receptors, adenosines, PSB11, hydrochloride, Tocris Bioscience, Adenosine A3 Receptor Antagonist products

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