Tomoxetine hydrochloride

Cat. No. 2011

Tomoxetine hydrochloride C17H21NO.HCl [82248-59-7]

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Alternative Names: Atomoxetine, LY 139603

Chemical Name: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride

Biological Activity

Potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.

Technical Data

M.Wt:
291.82
Formula:
C17H21NO.HCl
Solubility:
Soluble to 50 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
82248-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bymaster et al (2002) Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27 699. PMID: 12431845.

Wong et al (1982) A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 222 61. PMID: 6123593.

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Keywords: Tomoxetine hydrochloride, supplier, Potent, selective, noradrenaline, noradrenalin, reuptake, inhibitors, inhibits, Transporters, adrenaline, adrenalin, NET, Adrenergic, Monoamine, Neurotransmitter, LY139603, Tocris Bioscience, Adrenergic Transporter Inhibitor products

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