Tomoxetine hydrochloride

Cat. No. 2011

Tomoxetine hydrochloride C17H21NO.HCl [82248-59-7]

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Alternative Names: Atomoxetine, LY 139603

Chemical Name: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride

Biological Activity

Potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.

Technical Data

M.Wt:
291.82
Formula:
C17H21NO.HCl
Solubility:
Soluble to 50 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
82248-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bymaster et al (2002) Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27 699. PMID: 12431845.

Wong et al (1982) A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 222 61. PMID: 6123593.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Tomoxetine hydrochloride include:

Achterberg et al (2015) Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats. Psychopharmacology (Berl) 35 161. PMID: 25568111.

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. J Neurosci 352 53. PMID: 25332454.

Finnema et al (2015) Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain. Toxins (Basel) 18. PMID: 25522417.

Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. Int J Neuropsychopharmacol 231 2671. PMID: 24481568.

Do you know of a great paper that uses Tomoxetine hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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