SKF 86002 dihydrochloride

Cat. No. 2008

SKF 86002 dihydrochloride C16H12FN3S.2HCl [116339-68-5]

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Chemical Name: 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole dihydrochloride

Biological Activity

Inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo.

Technical Data

M.Wt:
370.27
Formula:
C16H12FN3S.2HCl
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
116339-68-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Nick et al (1997) Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J.Clin.Invest. 99 975. PMID: 9062356.

Lee et al (1994) A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis. Nature 372 739. PMID: 7997261.

Griswold et al (1987) SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem.Pharmacol. 36 3463. PMID: 2823821.

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Citations are publications that use Tocris products. Selected citations for SKF 86002 dihydrochloride include:

Haas et al (2013) The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog 9 e1003737. PMID: 24244164.

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Keywords: SKF 86002 dihydrochloride, supplier, p38, MAP, kinases, inhibitors, inhibits, anti-inflammatory, agent, human, monocyte, IL-1, TNF-α, TNF-alpha, production, Mitogen-Activated, Protein, Kinase, MAPK, Signaling, Signalling, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, SKF86002, dihydrochloride, Tocris Bioscience, p38 MAPK Inhibitor products

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