Fluticasone propionate

Cat. No. 2007

Fluticasone propionate C25H31F3O5S [80474-14-2]

Price and Availability

For Fluticasone propionate pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester

Biological Activity

High affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
500.57
Formula:
C25H31F3O5S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
80474-14-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Pan et al (2012) Potentiation of the Kv1 family K+ channel by cortisone analogues. ACS Chem.Biol. 7 1641. PMID: 22803826.

Zhang et al (2000) Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone. Eur.J.Pharmacol. 406 325. PMID: 11040338.

Smith and Kreutner (1998) In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch. 48 956.

Johnson (1995) The anti-inflammatory profile of fluticasone propionate. Allergy 50 11. PMID: 7604948.

If you know of a relevant reference for Fluticasone propionate please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Fluticasone propionate from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Fluticasone propionate, supplier, Selective, high, affinity, glucocorticoid, agonists, Receptors, GlaxoSmithKline, GSK, Tocris Bioscience, Glucocorticoid Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

Asthma Life Science Poster

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

Depression Life Science Poster

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

New Products in this Area

Megestrol Acetate

Synthetic progesterone analog

C-DIM 12

Nurr1 activator; inhibits NF-κB-dependent gene expression

(S)-Equol

Potent estrogen receptor β (ERβ) agonist

Ailanthone

Potent inhibitor of androgen receptor (AR)

(±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

AGN 193109

High affinity pan-RAR antagonist

SR 9243

Selective LXR inverse agonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.