Ro 31-8220 mesylate

Cat. No. 2002

Ro 31-8220 mesylate C25H23N5O2S.CH3SO3H [138489-18-6]

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Alternative Name: Bisindolylmaleimide IX

Chemical Name: 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate

Biological Activity

Protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range.

Technical Data

M.Wt:
553.65
Formula:
C25H23N5O2S.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
>97 %
Storage:
Desiccate at -20°C
CAS No:
138489-18-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. PMID: 10998351.

Lingameneni et al (2000) Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' protein kinase C inhibitor. FEBS Lett. 473 265. PMID: 10812087.

Standaert et al (1999) RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes. Comparison to actions of insulin. Endocrinology 150 2145.

Davis et al (1989) Potent, selective inhibitors of protein kinase C. FEBS Lett. 259 61. PMID: 2532156.

If you know of a relevant reference for Ro 31-8220 mesylate please let us know.

Citations are publications that use Tocris products. Selected citations for Ro 31-8220 mesylate include:

Mou et al (2016) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells Cell: Stem Cell 19 217. PMID: 27320041.

Tang et al (2015) Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Brain 5 14099. PMID: 26370265.

Bayliss and Evans (2013) Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS One 8 e80833. PMID: 24265838.

Do you know of a great paper that uses Ro 31-8220 mesylate from Tocris? If so please let us know.

View Related Products by Target

Keywords: Ro 31-8220 mesylate, supplier, Protein, kinases, inhibitors, inhibits, Broad, Spectrum, Ro31-8220, mesylate, Tocris Bioscience, Broad Spectrum Protein Kinase Inhibitor Inhibitor products

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