Cat. No. 1998
Biological ActivityPotent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.
(Modifications: Lys-1 - Lys-2 peptide bond replace with Ψ(CH2-NH))
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Torup et al (2003) Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 351 173. PMID: 14623134.
Dubuc et al (1992) JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 219 327. PMID: 1425958.
Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191. PMID: 1812009.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses JMV 449 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: JMV 449, supplier, Potent, neurotensin, receptor, agonists, NT, Receptors, JMV449, Tocris Bioscience, Neurotensin Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonistNeuropeptide S (Mouse)
Potent endogenous neuropeptide S receptor (NPSR) agonistML 382
MrgX1 (SNSR4) positive allosteric modulatorK-(D-1-Nal)-FwLL-NH2
High affinity and potent ghrelin receptor inverse agonistNeuropeptide S (Rat)
Potent endogenous neuropeptide S receptor agonistNeuropeptide S (human)
Potent endogenous neuropeptide S receptor agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.