Ro 15-4513

Cat. No. 1997

Ro 15-4513 C15H14N6O3 [91917-65-6]

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Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

Biological Activity

High affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

Technical Data

M.Wt:
326.31
Formula:
C15H14N6O3
Solubility:
Soluble to 5 mM in ethanol and to 10 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
91917-65-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Knoflach et al (1996) Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 50 1253. PMID: 8913357.

Wong and Skolnick (1992) High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63. PMID: 1311690.

Suzdak et al (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 1243. PMID: 3022383.

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Citations are publications that use Tocris products. Selected citations for Ro 15-4513 include:

Tracy et al (2016) Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice. Psychopharmacology 233 715. PMID: 26612620.

Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Neurosci 64 145. PMID: 22732440.

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Keywords: Ro 15-4513, supplier, Benzodiazepine, partial, inverse, agonists, GABAA, Receptors, Ro15-4513, Tocris Bioscience, GABAA Receptor Benzodiazepine products

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