ZK 93426 hydrochloride

Cat. No. 1996

ZK 93426 hydrochloride C18H20N2O3.HCl [1216792-30-1]

Price and Availability

For ZK 93426 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-Methyl-5-(1-methylethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride

Biological Activity

Potent, selective and competitive benzodiazepine receptor antagonist (IC50 values are 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar in vivo profile to flumazenil (Ro 15-1788, Cat No. 1328); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.

Technical Data

M.Wt:
348.82
Formula:
C18H20N2O3.HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1216792-30-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Corda et al (1987) Enhancement of γ-aminobutyric acid binding by the anxiolytic β-carbolines ZK 93423 and ZK 91296. J.Neurochem. 48 1355. PMID: 2881979.

File and Baldwin (1987) Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 19 293. PMID: 3315125.

Jensen et al (1984) Evaluation of the β-carboline ZK 93 426 as a benzodiazepine receptor antagonist. Psychopharmacology 83 249. PMID: 6089247.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses ZK 93426 hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: ZK 93426 hydrochloride, supplier, Potent, competitive, benzodiazepine, antagonists, GABAA, Receptors, ZK93426, hydrochloride, Tocris Bioscience, GABAA Receptor Benzodiazepine products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GABA Review

Written by I. Martin et al

GABA Receptors Scientific Review

Our GABA review gives an overview of the structure and function of the GABA receptors, as well as highlighting pharmacological ligands for their study. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

Mechanisms of Addiction

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

divider line

Bio-Techne Events

ASCB 2016

ASCB 2016

December 3 - 7, 2016

San Francisco, CA,

Booth: 314