Cat. No. 1995
Chemical Name: 5,6-Dihydro-5-methyl-6-oxo-4H-imida
Biological ActivityBenzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
June et al (1998) The novel benzodiazepine inverse agonist RO19-4603 antagonises ethanol motivated behaviours: neuropharmacological studies. Brain Res. 784 256. PMID: 9518641.
June et al (1995) Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of tolerance to a single dose of ethanol. J.Pharmacol.Exp.Ther. 274 1105. PMID: 7562476.
Wong and Skolnick (1992) High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63. PMID: 1311690.
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Keywords: Ro 19-4603, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, Ro19-4603, Tocris Bioscience, GABAA Receptor Benzodiazepine products