ZK 93423 hydrochloride

Cat. No. 1994

ZK 93423 hydrochloride C23H22N2O4.HCl
 [1216574-52-5]

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Chemical Name: 4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride

Biological Activity

Potent benzodiazepine receptor agonist (IC50 = 1 nM). Non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors (Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively). Anxiolytic following systemic administration in vivo.

Technical Data

M.Wt:
426.9
Formula:
C23H22N2O4.HCl
Solubility:
Soluble to 30 mM in DMSO and to 5 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1216574-52-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cox et al (1998) Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK 93423) at wild type and recombinant GABAA receptors. J.Med.Chem. 41 2537. PMID: 9651158.

File and Baldwin (1987) Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 19 293. PMID: 3315125.

Stephens et al (1984) Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors. Psychopharmacology 83 233. PMID: 6089245.

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Keywords: ZK 93423 hydrochloride, supplier, Potent, benzodiazepine, agonists, GABAA, Receptors, ZK93423, hydrochloride, Tocris Bioscience, GABAA Receptor Benzodiazepine products

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