Cat. No. 1989
Biological ActivityPeptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Holzberg et al (2003) Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN d domain induces apoptosis and affects a distinct set of interleukin-1 induced inflammatory genes. J.Biol.Chem. 278 40213. PMID: 12832416.
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Citations are publications that use Tocris products. Selected citations for c-JUN peptide include:
Moreau et al (2015) Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. J Urol 6 8045. PMID: 26289944.
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Keywords: c-JUN peptide, supplier, JNK, c-Jun, interaction, inhibitors, inhibits, Peptide, N-Terminal, Kinases, Transcription, Factors, Mitogen-Activated, protein, Tocris Bioscience, JNK/c-Jun Inhibitor products
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