Cat. No. 1983
Alternative Name: PDGFR740Y-P
Biological ActivityCell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.
(Modifications: Tyr-21 = pTyr)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272. PMID: 10328886.
Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148.
If you know of a relevant reference for 740 Y-P please let us know.
Citations are publications that use Tocris products. Selected citations for 740 Y-P include:
Sun et al (2015) New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators. Cell Cycle 14 721. PMID: 25590233.
Sun et al (2015) Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway. J Assist Reprod Genet 83 86. PMID: 25284282.
Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134. PMID: 24266887.
Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627. PMID: 24121738.
Lerer-Serfaty et al (2013) Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles. Proc Natl Acad Sci U S A 30 1279. PMID: 23934019.
Li et al (2010) Activation of dormant ovarian follicles to generate mature eggs. Nat Commun 107 10280. PMID: 20479243.
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Keywords: 740 Y-P, supplier, Cell-permeable, PI, 3-kinase, activators, PI3K, 740YP, phosphopeptide, activator, p85, Tocris Bioscience, PI 3-kinase Activator products
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