Reboxetine mesylate

Cat. No. 1982

Reboxetine mesylate C19H23NO3.CH3SO3H [98769-84-7]

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Chemical Name: (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate

Biological Activity

Potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

Technical Data

M.Wt:
409.5
Formula:
C19H23NO3.CH3SO3H
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
98769-84-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Owen and Whitton (2003) Reboxetine modulates norepinephrine efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors. Neurosci.Lett. 348 171. PMID: 12932821.

Millan et al (2001) S33005, a novel ligand at both serotonin and norepinephrine transporters: I Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. J.Pharmacol.Exp.Ther. 298 565. PMID: 11454918.

Wong et al (2000) Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor. Biol.Psychiatry. 47 818. PMID: 10812041.

Sacchetti et al (1999) Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain. Br.J.Pharmacol. 128 1332. PMID: 10578149.

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