Reboxetine mesylate

Cat. No. 1982

Reboxetine mesylate C19H23NO3.CH3SO3H [98769-84-7]

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Chemical Name: (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate

Biological Activity

Potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

Technical Data

M.Wt:
409.5
Formula:
C19H23NO3.CH3SO3H
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
98769-84-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Owen and Whitton (2003) Reboxetine modulates norepinephrine efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors. Neurosci.Lett. 348 171. PMID: 12932821.

Millan et al (2001) S33005, a novel ligand at both serotonin and norepinephrine transporters: I Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. J.Pharmacol.Exp.Ther. 298 565. PMID: 11454918.

Wong et al (2000) Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor. Biol.Psychiatry. 47 818. PMID: 10812041.

Sacchetti et al (1999) Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain. Br.J.Pharmacol. 128 1332. PMID: 10578149.

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Citations are publications that use Tocris products. Selected citations for Reboxetine mesylate include:

Munari et al (2015) Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects. Neurochem Int 18 pyv045. PMID: 25899065.

Hughes et al (2013) Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. Int J Neuropsychopharmacol 154 1680. PMID: 23707289.

Ferreira et al (2012) Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. Theriogenology 61 219. PMID: 22609378.

Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Pain 37 321. PMID: 21956448.

Do you know of a great paper that uses Reboxetine mesylate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Reboxetine mesylate, supplier, Potent, selective, noradrenalin, noradrenaline, reuptake, inhibitors, inhibits, orally, active, Transporters, NET, Adrenergic, adrenaline, adrenalin, Monoamine, Neurotransmitter, Tocris Bioscience, Adrenergic Transporter Inhibitor products

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