L-817,818

Cat. No. 1980

L-817,818 C33H36N4O3 [217480-27-8]

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Chemical Name: N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester

Biological Activity

Potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro.

Technical Data

M.Wt:
536.67
Formula:
C33H36N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
217480-27-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Rohrer and Schaeffer (2000) Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 94 211. PMID: 11087999.

Strowski et al (2000) Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 141 111. PMID: 10614629.

Rohrer et al (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282 737. PMID: 9784130.

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Keywords: L-817,818, supplier, Potent, selective, sst5, agonists, Receptors, Somatostatin, L817818, Tocris Bioscience, Somatostatin (sst) Receptor Agonist products

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