6-Iodonordihydrocapsaicin

Cat. No. 1975

6-Iodonordihydrocapsaicin C17H26INO3 [859171-97-4]

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Biological Activity

Potent competitive vanilloid TRPV1 (VR1) receptor antagonist (IC50 = 10 nM). Inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro.

Technical Data

M.Wt:
419.3
Formula:
C17H26INO3
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
859171-97-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Appendino et al (2003) Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists. Br.J.Pharmacol. 139 1417. PMID: 12922928.

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Keywords: 6-Iodonordihydrocapsaicin, supplier, Potent, competitive, vanilloids, receptors, antagonists, VR1, TRPV, Channels, Transient, Receptor, Potential, Tocris Bioscience, TRPV Antagonist products

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