Cat. No. 1975
Biological ActivityPotent competitive vanilloid TRPV1 (VR1) receptor antagonist (IC50 = 10 nM). Inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Appendino et al (2003) Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists. Br.J.Pharmacol. 139 1417. PMID: 12922928.
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Keywords: 6-Iodonordihydrocapsaicin, supplier, Potent, competitive, vanilloids, receptors, antagonists, VR1, TRPV, Channels, Transient, Receptor, Potential, Tocris Bioscience, TRPV Antagonist products
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