SANT-1

Cat. No. 1974

SANT-1 C23H27N5 [304909-07-7]

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Chemical Name: N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

Biological Activity

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).

Technical Data

M.Wt:
373.5
Formula:
C23H27N5
Solubility:
Soluble to 25 mM in ethanol and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
304909-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chen et al (2002) Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci.USA. 99 1407.

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Citations are publications that use Tocris products. Selected citations for SANT-1 include:

Nostro et al (2015) Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Neuropsychopharmacology 4 591. PMID: 25843049.

Atwood et al (2013) GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas. Stem Cell Reports 494 484. PMID: 23446420.

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Keywords: SANT-1, supplier, inhibitors, inhibits, hedgehog, Hh, signaling, antagonizes, smoothened, activity, Signaling, Signalling, Smo, Receptors, antagonist, Tocris Bioscience, Hedgehog Signaling Inhibitor products

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