Tianeptine sodium salt

Cat. No. 1972

Tianeptine sodium salt C21H24ClN2NaO4S [30123-17-2]

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Chemical Name: 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid sodium salt

Biological Activity

Selective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

Technical Data

M.Wt:
458.93
Formula:
C21H24ClN2NaO4S
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
30123-17-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Plaisant et al (2003) Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology 44 801. PMID: 12681378.

Uzbay et al (1999) Analgesic effect of tianeptine in mice. Life Sci. 64 1313. PMID: 10227587.

Kato and Weitsch (1988) Neurochemical profile of tianeptine, a new antidepressant drug. Clin.Neuropharmacol. 11 S43. PMID: 3052825.

Mennini et al (1987) Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmied.Arch.Pharmacol. 336 478.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Tianeptine sodium salt include:

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Nature 40 766. PMID: 25249058.

Makani et al (2013) Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells. Mol Cell Endocrinol 381 175. PMID: 23933152.

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Keywords: Tianeptine sodium salt, supplier, Selective, facilitator, 5-HT, reuptake, antidepressant, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter products

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