Norketamine hydrochloride

Cat. No. 1970

Norketamine hydrochloride C12H14ClNO.HCl [79499-59-5]

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Chemical Name: 2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride

Biological Activity

Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo. R-enantiomer and S-enantiomer also available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
260.16
Formula:
C12H14ClNO.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
79499-59-5

Resources

Other Information

R-enantiomer and S-enantiomer also available.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Shimoyama et al (1999) Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. Pain 81 85. PMID: 10353496.

Ebert et al (1997) Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 333 99. PMID: 9311667.

Leung et al (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396. PMID: 3783598.

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Keywords: Norketamine hydrochloride, supplier, Potent, non-competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Pfizer, Tocris Bioscience, Ketamine and Metabolite products

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