Cat. No. 1966
Chemical Name: (5Z,8Z,11Z,14Z)-N-(3-Furanylmethyl)
Biological ActivityPotent endocannabinoid transport inhibitor. IC50 values are 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH respectively. Ki values are 4700, 67 and > 5000 nM for CB1, CB2 and VR1 receptors respectively. Potentiates hypokinetic and antinociceptive effects of anandamide in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lopez-Rodriguez et al (2003) Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. Eur.J.Med.Chem. 38 403. PMID: 12750028.
Lopez-Rodriguez et al (2003) Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. J.Med.Chem. 46 1512. PMID: 12672252.
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Keywords: UCM 707, supplier, Potent, anandamide, transporters, inhibitors, inhibits, AMT, Anandamide, cannabinoids, Monoamine, Neurotransmitter, UCM707, Tocris Bioscience, Cannabinoid Transporter Inhibitor products
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