Simvastatin

Cat. No. 1965

Simvastatin C25H38O5 [79902-63-9]

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Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate

Biological Activity

HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data

M.Wt:
418.57
Formula:
C25H38O5
Solubility:
Soluble to 50 mM in DMSO and to 75 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
79902-63-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Kaushal et al (2003) Potential anticancer effects of statins: fact or fiction? Endothelium 10 49. PMID: 12699077.

Reinoso et al (2002) Preclinical pharmacokinetics of statins. Methods Find.Exp.Clin.Pharmacol. 24 593. PMID: 12616706.

Garrett et al (2001) Statins and bone formation. Curr.Pharm.Des. 7 715. PMID: 11405194.

White (1999) Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol. 39 111. PMID: 11563401.

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Keywords: Simvastatin, supplier, HMG-CoA, reductase, inhibitors, inhibits, Reductases, Tocris Bioscience, HMG-CoA Reductase Inhibitor products

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