Cat. No. 1965

Simvastatin C25H38O5 [79902-63-9]

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Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate

Biological Activity

HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data

Soluble to 50 mM in DMSO and to 75 mM in ethanol
>98 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kaushal et al (2003) Potential anticancer effects of statins: fact or fiction? Endothelium 10 49. PMID: 12699077.

Reinoso et al (2002) Preclinical pharmacokinetics of statins. Methods Find.Exp.Clin.Pharmacol. 24 593. PMID: 12616706.

Garrett et al (2001) Statins and bone formation. Curr.Pharm.Des. 7 715. PMID: 11405194.

White (1999) Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol. 39 111. PMID: 11563401.

If you know of a relevant reference for Simvastatin please let us know.

Citations are publications that use Tocris products. Selected citations for Simvastatin include:

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Br J Pharmacol 8 e66404. PMID: 23799098.

Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Pharmacol Res Perspect 2 1176. PMID: 22202492.

Seto et al (2007) Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. Oncotarget 151 987. PMID: 17558433.

Do you know of a great paper that uses Simvastatin from Tocris? If so please let us know.

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Keywords: Simvastatin, supplier, HMG-CoA, reductase, inhibitors, inhibits, Reductases, Tocris Bioscience, HMG-CoA Reductase Inhibitor products

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