Cat. No. 1963
Chemical Name: N-(6,8-Difluoro-2-methyl-4-quinolin
Biological ActivitySelective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Langmead et al (2004) Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 141 340. PMID: 14691055.
Porter (2001) Advances in novel 7-TM receptors: non-peptide orexin-1 antagonists. Royal Society of Chemistry Meeting..
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Keywords: SB 408124, supplier, Selective, non-peptide, OX1, antagonists, Orexin1, Receptors, SB408124, GlaxoSmithKline, GSK, Tocris Bioscience, OX1 Receptor Antagonist products