SB 258585 hydrochloride
Cat. No. 1961
Chemical Name: 4-Iodo-N-[4-methoxy-3-(4-methyl-1-p
Biological ActivityPotent and selective 5-HT6 receptor antagonist (pKi = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
East et al (2002) 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585. Synapse 45 191. PMID: 12112397.
Hirst et al (2000) Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue. Br.J.Pharmacol. 130 1597. PMID: 10928963.
Bromidge et al (1999) 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J.Med.Chem. 42 202. PMID: 9925723.
If you know of a relevant reference for SB 258585 hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for SB 258585 hydrochloride include:
Yun et al (2016) Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor. Scientific Reports 6 30985. PMID: 27581523.
Do you know of a great paper that uses SB 258585 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SB 258585 hydrochloride, supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, SB258585, hydrochloride, GlaxoSmithKline, GSK, Tocris Bioscience, 5-HT6 Receptor Antagonist products