DMeOB

Cat. No. 1953

DMeOB C16H16N2O2 [40252-74-2]

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Chemical Name: [(3-Methoxyphenyl)methylene]hydrazone-3-methoxybenzaldehyde

Biological Activity

Negative allosteric modulator of the metabotropic glutamate receptor mGlu5; displays reversible non-competitive inhibition of mGlu5-mediated responses (IC50 = 3 μM).

Technical Data

M.Wt:
268.31
Formula:
C16H16N2O2
Solubility:
Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
40252-74-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

O'Brien et al (2003) A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 Mol.Pharmacol. 64 731. PMID: 12920211.

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Citations are publications that use Tocris products.

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Keywords: DMeOB, supplier, Negative, allosteric, modulators, mGlu5, mGluR5, Group, I, Receptors, Glutamate, Metabotropic, nams, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products

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