DCB

Cat. No. 1952

DCB C14H10Cl2N2 [6971-97-7]

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Alternative Name: 3,3'-Dichlorobenzaldazine

Chemical Name: [(3-Chlorophenyl)methylene]hydrazone-3-chlorobenzaldehyde

Biological Activity

Allosteric ligand for the metabotropic glutamate receptor mGlu5; displays neutral modulation. Does not affect agonist-stimulated mGlu5 responses, but blocks regulation of the receptor by other allosteric modulators such as DFB (Cat. No. 1625) and DMeOB (Cat. No. 1953).

Technical Data

M.Wt:
277.15
Formula:
C14H10Cl2N2
Solubility:
Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
6971-97-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

O'Brien et al (2003) A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol.Pharmacol. 64 731. PMID: 12920211.

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Keywords: DCB, supplier, Allosteric, modulators, mGlu5, mGluR5, Group, I, Receptors, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products

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