Cat. No. 2983
Alternative Names: Galardin, Ilomastat
Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indo
Biological ActivityBroad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Shichi et al (2011) Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 338 701. PMID: 21602423.
Chao et al (2007) Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 573 49. PMID: 17678888.
Grobelny et al (1992) Inhibition of skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31 7152. PMID: 1322694.
If you know of a relevant reference for GM 6001 please let us know.
Citations are publications that use Tocris products. Selected citations for GM 6001 include:
Schumacher (2017) ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis 8 e2622. PMID: 28230865.
Bras et al (2015) TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. PLoS One 330 29. PMID: 25064463.
Greene et al (2015) CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells. Proc Natl Acad Sci U S A 10 e0144133. PMID: 26710229.
Son et al (2015) Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Mol Neurodegener 10 56. PMID: 26520569.
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Keywords: GM 6001, supplier, GM6001, matrix, metalloproteases, metalloproteinases, MMPs, broad-spectrum, inhibitors, inhibits, Ilomastat, Galardin, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
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