Bupropion hydrochloride

Cat. No. 2831

Bupropion hydrochloride C13H18ClNO.HCl [31677-93-7]

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Chemical Name: 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride

Biological Activity

Non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.

Technical Data

M.Wt:
276.2
Formula:
C13H18ClNO.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
31677-93-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Dwoskin et al (2006) Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent. CNS Drug Rev. 12 178. PMID: 17227286.

Torres et al (2003) Plasma membrane monoamine transporters: structure regulation and function. Nat.Rev.Neurosci. 4 13. PMID: 12511858.

Slemmer et al (2000) Bupropion is a nicotinic antagonist. J.Pharmacol.Exp.Ther. 295 321. PMID: 10991997.

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Keywords: Bupropion hydrochloride, supplier, Non-Selective, inhibitors, inhibits, dopamine, noradrenaline, transporters, NET, Adrenergic, Monoamine, Neurotransmitter, DAT, Dopamine, reuptake, Tocris Bioscience, Dopamine Transporter Inhibitor products

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