Cat. No. 2668
Alternative Name: Qinghaosu
Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-Octahyd
Biological ActivityAntimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Eckstein-Ludwig et al (2003) Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 957. PMID: 12931192.
Wartenberg et al (2003) The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab.Invest. 83 1647. PMID: 14615418.
Balint (2001) Artemisinin and its derivatives. An important new class of antimalarial agents. Pharmacol.Ther. 90 261. PMID: 11578659.
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Keywords: Artemisinin, supplier, Antimalarial, inhibits, inhibitors, P-type, ATPase, PfATP6, P, falciparum, Calcium-ATPase, SERCA, PMCA, Ca2+-ATPase, Ion, Transporters, Pumps, P-Type, V-Type, E-Type, F-Type, ATPases, GTPases, Ca2+, modulators, Signaling, Signalling, Calcium, Tocris Bioscience, Ca2+-ATPase Inhibitor products