Artemisinin

Cat. No. 2668

Artemisinin C15H22O5 [63968-64-9]

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Alternative Name: Qinghaosu

Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

Biological Activity

Antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.

Technical Data

M.Wt:
282.33
Formula:
C15H22O5
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
63968-64-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Eckstein-Ludwig et al (2003) Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 957. PMID: 12931192.

Wartenberg et al (2003) The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab.Invest. 83 1647. PMID: 14615418.

Balint (2001) Artemisinin and its derivatives. An important new class of antimalarial agents. Pharmacol.Ther. 90 261. PMID: 11578659.

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Keywords: Artemisinin, supplier, Antimalarial, inhibits, inhibitors, P-type, ATPase, PfATP6, P, falciparum, Calcium-ATPase, SERCA, PMCA, Ca2+-ATPase, Ion, Transporters, Pumps, P-Type, V-Type, E-Type, F-Type, ATPases, GTPases, Ca2+, modulators, Signaling, Signalling, Calcium, Tocris Bioscience, Ca2+-ATPase Inhibitor products

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