Gap 26

Cat. No. 1950

Gap 26 Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg

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Biological Activity

Peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 mM). Also inhibits IP3-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.

Technical Data

M.Wt:
1550.79
Formula:
C70H107N19O19S
Sequence:
VCYDKSFPISHVR
Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
197250-15-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Braet et al (2003) Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 33 37. PMID: 12526886.

Chaytor et al (1997) Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J.Physiol. 503 99. PMID: 9288678.

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Citations are publications that use Tocris products. Selected citations for Gap 26 include:

Jones et al (2015) Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Sci Rep 5 11694. PMID: 26170169.

Thuringer et al (2015) Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. BMC Vet Res 6 10267. PMID: 25868858.

Sakatani et al (2008) Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo. J Neurosci 28 10928. PMID: 18945900.

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Keywords: Gap 26, supplier, Gap, junction, blockers, connexin, 43, channels, modulators, Gap26, Tocris Bioscience, Gap Channel Blocker products

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