Cat. No. 1950
Biological ActivityPeptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 mM). Also inhibits IP3-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Braet et al (2003) Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 33 37. PMID: 12526886.
Chaytor et al (1997) Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J.Physiol. 503 99. PMID: 9288678.
If you know of a relevant reference for Gap 26 please let us know.
Citations are publications that use Tocris products. Selected citations for Gap 26 include:
Jones et al (2015) Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Sci Rep 5 11694. PMID: 26170169.
Thuringer et al (2015) Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. BMC Vet Res 6 10267. PMID: 25868858.
Sakatani et al (2008) Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo. J Neurosci 28 10928. PMID: 18945900.
Do you know of a great paper that uses Gap 26 from Tocris? If so please let us know.
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Keywords: Gap 26, supplier, Gap, junction, blockers, connexin, 43, channels, modulators, Gap26, Tocris Bioscience, Gap Channel Blocker products
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