L-670,596

Cat. No. 1949

L-670,596 C22H21F2NO4S [121083-05-4]

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Chemical Name: (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid

Biological Activity

Potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist (IC50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA2 = 9.0) and human platelet aggregation in vitro (IC50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo.

Technical Data

M.Wt:
433.47
Formula:
C22H21F2NO4S
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
121083-05-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Beauchamp et al (2001) Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy. J.Appl.Physiol. 90 2279. PMID: 11356793.

Ford-Hutchinson et al (1989) The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can.J.Physiol.Pharmacol. 67 989. PMID: 2598135.

Girard et al (1989) Tetrahydrocarbazol-1-acetic acids: new class of thromboxane receptor antagonists. Prog.Clin.Biol.Res. 301 585. PMID: 2529558.

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Keywords: L-670,596, supplier, Potent, selective, thromboxane, A2, endoperoxide, antagonists, TP, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L670596, Tocris Bioscience, Prostanoid Receptor Antagonist products

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