PR 39 (porcine)

Cat. No. 1947

PR 39 Arg-Arg-Arg-Pro-Arg-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Pro-Phe-Phe-Pro-Pro-Arg-Leu-Pro-Pro-Arg-Ile-Pro-Pro-Gly-Phe-Pro-Pro-Arg-Phe-Pro-Pro-Arg-Phe-Pro-NH2

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Biological Activity

Antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα.

Technical Data

M.Wt:
4719.7
Formula:
C229H346N70O40
Sequence:
RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP

(Modifications: Pro-39 = C-terminal amide)

Storage:
Desiccate at -20°C
CAS No:
139637-11-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Gaczynska et al (2003) Proline and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry 42 8663. PMID: 12873125.

Gao et al (2000) Inhibition of ubiquitin-proteasome pathway-mediated IκBα degradation by a naturally occuring antibacterial peptide. J.Clin.Invest. 106 439. PMID: 10930447.

Li et al (2000) PR39, a peptide regulator of angiogenesis. Nat.Med. 6 356. PMID: 10613823.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PR 39 (porcine) include:

Yan et al (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol 63 420. PMID: 25828472.

Do you know of a great paper that uses PR 39 (porcine) from Tocris? If so please let us know.

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Keywords: PR 39, supplier, IκB, IκBα, IkappaBalpha, blocks, degradation, inhibitors, inhibits, NF-κB, NF-kappaB, Nf-kB, Transcription, Factors, Nuclear, Factor, Kappa, B, PR39, Tocris Bioscience, NF-κB and IκB Inhibitor products

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