ST 91

Cat. No. 2638

ST 91 C13H19N3.HCl [4749-61-5]

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Chemical Name: N-(2,6-Diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

Biological Activity

α2-adrenoceptor agonist that does not cross the blood brain barrier. Displays ~ 120-fold selectivity for α2 receptors over α1 receptors and acts predominantly at non-α2A-adrenoceptors which may be of the α2C subtype. Antinociceptive; increases tail-flick latencies in Sasco and Harlan rats.

Technical Data

M.Wt:
253.77
Formula:
C13H19N3.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
4749-61-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Graham et al (2000) Synergistic interactions between two α2-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain 85 135. PMID: 10692612.

Celly et al (1999) Cardiopulmonary effects of the α2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. J.Pharmacol.Exp.Ther. 289 712. PMID: 10215644.

Takano and Yaksh (1992) Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J.Pharmacol.Exp.Ther. 261 764. PMID: 1349648.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ST 91 include:

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110. PMID: 21315691.

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