Cat. No. 2638
Chemical Name: N-(2,6-Diethylphenyl)-4,5-dihydro-1
Biological Activityα2-adrenoceptor agonist that does not cross the blood brain barrier. Displays ~ 120-fold selectivity for α2 receptors over α1 receptors and acts predominantly at non-α2A-adrenoceptors which may be of the α2C subtype. Antinociceptive; increases tail-flick latencies in Sasco and Harlan rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Graham et al (2000) Synergistic interactions between two α2-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain 85 135. PMID: 10692612.
Celly et al (1999) Cardiopulmonary effects of the α2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. J.Pharmacol.Exp.Ther. 289 712. PMID: 10215644.
Takano and Yaksh (1992) Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J.Pharmacol.Exp.Ther. 261 764. PMID: 1349648.
If you know of a relevant reference for ST 91 please let us know.
Citations are publications that use Tocris products. Selected citations for ST 91 include:
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110. PMID: 21315691.
Do you know of a great paper that uses ST 91 from Tocris? If so please let us know.
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Keywords: ST 91, supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, putative, α2C-adrenoceptor, alpha2C-adrenoceptors, α2c-adrenergic, alpha2c-adrenergic, a2c-adrenoceptor, a2c-adrenergic, Receptors, ST91, Tocris Bioscience, Adrenergic α2 Receptor Agonist products